Should I take loratadine or cetirizine hydrochloride

Loratadine and cetirizine are both anti-histamines used for treating allergic conditions such as rhinitis, colds, pruritus, urticarial rashes, sneezing, allergic conjunctivitis, and nasal congestion. The question is - should I take loratadine or cetirizine hydrochloride

Loratadine and cetirizine are both anti-histamines used for treating allergic conditions such as rhinitis, colds, pruritus, urticarial rashes, sneezing, allergic conjunctivitis, and nasal congestion. The question is – should I take loratadine or cetirizine hydrochloride?

Loratadine is a cyproheptadine derivative. It is a long-acting and potent tricyclic H1-antihistamine drug. It selectively antagonizes the histamine H1 receptor. H1 receptors cause vasodilation, contraction of the smooth muscles in the bronchi and the GI tract, itching in the skin, flare.

Cetirizine hydrochloride, on the other hand, is a piperazine derivative. It is also a long-acting and less sedative. It reduces the actions of histamine by blocking its receptors in the body tissues.

Taking Loratadine or Cetirizine

Loratadine and cetirizine belong to the same class of drugs – antihistamines. They belong to the second generation of anti-histamines. It is worthy to note that second-generation anti-histamines have an advantage over first-generation drugs. They have fewer nervous side effects like drowsiness. Both cetirizine alongside loratadine is drugs of choice in treating allergies in breastfeeding mothers.

Loratadine has a slower onset of action of about 3 hours but lasts for a full day. Cetirizine has a faster onset of action, with 1 hour peak serum time, and lasts for a shorter period of time.

Cetirizine has an advantage over loratadine like its faster onset of action. It is better than loratadine in treating hay fever. However, the action does not last long. It also causes more drowsiness than loratadine. It can also cause dry mouth when used to treat allergic rhinitis.

Loratadine is better when a longer duration of action is needed. It also has more decongestant properties and does not cause drowsiness. So you can take it and drive or work. Loratadine however interacts with many drugs especially alcohol, erythromycin, ketoconazole, carbamazepine, and other anti-histamines. It is not advisable to give it to renal impaired patients.

Post Disclaimer

The information contained in this post is to provide pharmaceutical and health information only. The information is provided by our qualified writers and reviewed by qualified healthcare professionals. We make sure the information here is not misleading, deceptive, or encourages any illegal behavior. Our information is up-to-date, insightful, and correct.

See also  Should I take diclofenac sodium or potassium?

However, we do not encourage you to self-medicate or abuse any form of medication. It is strictly recommended that you consult your doctor when you have any symptoms of ill-health.

About Vincent Jo, B. Pharm

A trained and fully licensed pharmacist by the Pharmacists Council of Nigeria. Vincent has four years experience as a pharmacist. He is a researcher and content writer for several blogs, forums and magazines focusing on health

View all posts by Vincent Jo, B. Pharm →

Leave a Reply

Your email address will not be published. Required fields are marked *